The Program

The OPTIFAST® program is a medically-supervised weight loss program that closely monitors and assesses progress towards better health and emotional well-being.

The OPTIFAST logo Difference

The OPTIFAST® program is a medically-supervised weight loss program that closely monitors and assesses progress towards better health and emotional well-being. Typical results at 26 weeks1:

Weight Loss


30 lb

at 26 weeks1

2x more weight loss compared to a reduced calorie
food-based program

Blood glucose levels



average decrease in blood pressure2

Blood pressure



average decrease in total cholesterol3

Decrease cholesterol



blood glucose levels vs. baseline4

Long Term Results


OPTIFAST® patients who actively participate in a 26-week program typically lose approximately 30 lbs. (2x more compared to a reduced-calorie food-based* program) and maintain approximately a 25-lb. weight loss at 1 year.1


OPTIFAST® patients maintained an average weight loss of approximately 19 lbs. after 2 years and 15 lbs. after 3 years from starting the program.5

How OPTIFAST logo Works

Our comprehensive weight loss program contains multiple components, including medical, nutritional, and behavioral support, to help you lose weight and improve your health. Click each subject to learn more.

Medical Monitoring

Evaluation and support of patients health and well-being throughout the program.

Nutrition Education

Strategies for successful long-term lifestyle change.

Exercise Guidance

Integrating activity into a weight loss program leads to greater success.

Patient Support

Website that helps keep patients motivated.

Full Meal Replacement

Nutritionally complete (in 5 servings) with at least 24 key vitamins & minerals.


Lifestyle Education

Lifestyle Education Series™ modules help patients relearn how to approach food and eating.

The Weight Loss Journey

Participation in the OPTIFAST® program includes 3 key phases designed to help patients lose weight by helping change their relationship with food and eating. Each patient receives an individual  evaluation to customize the program to meet their individual needs.


During this phase, the patient will eat a diet of OPTIFAST® full meal replacement products.


Self-prepared foods are gradually reintroduced into the diet, while patients attend classes to help change the way they think about and approach food and eating.


Patients should continue to attend ongoing support sessions to help them maintain their weight loss and manage weight long-term.

*modified version of Diabetes Prevention Program (DPP) diet

  1. Ard JD, Lewis KH, Rothberg A, et al. Effectiveness of a total meal replacement program (OPTIFAST® program) on weight loss: results from the OPTIWIN study. Obesity. 2018; doi: 10.1002/oby.22303.
  2. Ard JD, Schroeder MC, Kivilaid K, et al. Practical application of a comprehensive weight management program in patients with and without metabolic syndrome. J Obes Weight Loss Ther. 2014;S4:007.
  3. Drawert S, Bedford K, Largent D. Change in glucose, blood pressure, and cholesterol with weight loss in medically obese patients. Obes Res. 1996;4(Suppl 1):67S.
  4. Wadden TA, Foster GD, Letizia KA, Stunkard AJ. A multicenter evaluation of a proprietary weight reduction program for the treatment of marked obesity. Arch Intern Med. 1992;152(5):961-966.
  5. Krishnaswami A, Ashok R, Sidney S, et al. Real-World Effectiveness of a Medically Supervised Weight Management Program in a Large Integrated Health Care Delivery System: Five-Year Outcomes. Perm J. 2018;22:17-082.
  6. Hutcheon DA, et al. Short-Term Preoperative Weight Loss and Postoperative Outcomes in Bariatric Surgery. J Am Coll Surg. 2018;226:514-524. (doi:10.1016/j.jamcollsurg.2017.12.032)
  7. Tarnoff M, et al. An evidence based assessment of preoperative weight loss in bariatric surgery. Obes Surg.2008;18:1059-1061.