About the OPTIFAST Program - Clinically Proven Weight Loss | OPTIFAST

The OPTIFAST® program, which usually lasts 26 weeks, is a medically-supervised weight-management program that closely monitors and assesses progress towards better health and emotional well-being. The program utilizes a meal replacement plan that transitions to self-prepared ‘everyday’ meals, in conjunction with comprehensive patient education and support.

Proven Benefits

The OPTIFAST® program has over 40 years of experience and documented outcomes in more than 80 clinical weight loss publications.

Through weight loss, the OPTIFAST® program can help improve the state of certain medical conditions of patients related to their excess weight. This clinically proven program was designed to help patients improve their health by losing weight under medical supervision. 1-3

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Long-term Results

Losing at least 5% of one’s starting weight is considered “medically significant” because it is associated with improvements in risk factors or incidence of certain diseases and conditions in at-risk people who suffer from obesity2

  • After 2 years (based on approximately 610 participants in the study)

    40%of patients maintained more than half their weight loss

    78% of men and 60% of women maintained medically significant weight loss

  • After 5 years (based on approximately 335 participants)

    Approximately 50% of patients maintained medically significant weight loss

Phases and Patient Journey

Active Weight Loss




Long-term Management

MONTHS 6-24+
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*OPTIFAST® patients who actively participate in a 26-week program typically lose approximately 50 pounds.


  • Wadden TA, Foster GD, Letizia KA, Stunkard AJ. A multicenter evaluation of a proprietary weight reduction program for the treatment of marked obesity. Arch Intern Med. 1992 May;152(5):961-6.  
  • Wadden TA, Frey DL.  A Multicenter Evaluation of a Proprietary Weight Loss Program for the Treatment of Marked Obesity: A Five-Year Follow-Up.  International Journal of Eating Disorders. 1997;022:02:203-212.
  • Drawert S, Bedford K, Largent D. Change in glucose, blood pressure, and cholesterol with weight loss in medically obese patients. Obesity Research. 1996;4(S1)67S.
  • Ard J, Schroeder M, Kivilaid K, Swanson J, Hayes E, Olesen M. Effects of the practical application of a medically monitored, comprehensive weight management program on risk factors associated with the metabolic syndrome. International Journal of Obesity.  (Ard et al., J Obes Wt Loss Ther 2014, S4)