The program

The science-based program that delivers
weight loss for health gains

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THE OPTIWIN STUDY

OPTIWIN is a year-long, head-to-head study, designed to evaluate the effectiveness of a medically monitored, behavioral, meal replacement weight loss program (the OPTIFAST Program) on weight loss and maintenance, in comparison with a standard-of-care, reduced-energy, food-based diet (modiefied version of Diabetes Prevention Program, DPP) and lifestyle intervention among adults with a BMI higher than 30.

Study Design

Duration

52 weeks: 26-week weight loss phase, followed by a 26-week weight maintenance phase.

How?

Open-label, randomized, controlled trial

Where?

multicenter (9 sites across the U.S.)

Participants

330 eligible for study; 273 in the mITT* study population

Method

(n=135 mITT*)

ACTIVE PHASE:

  • Total meal replacement up to 16 weeks
  • 800 kcal/day, based on BMI
  • 40% carbohydrate, 40% protein, 20% fat
  • Gradual introduction of food up to 26 weeks

MAINTENANCE:

Conventional food, encouraged 1-2 meal replacements per day.

FOOD-BASED PROGRAM

(n-=138 mITT*)

ACTIVE PHASE:

  • Reduced energy (-500 to -750 kcal/day, 25% to 30% fat) diet based on modified Diabetes Prevention Program for 26 weeks.

MAINTENANCE:

Increased energy intake to achieve weight maintenance.

IN BOTH GROUPS

150-180 minutes per week of moderate to vigorous intensity exercise
Group (weekly) and individual (per schedule) behavioral counseling sessions

Results

Mean weight loss (%)

Patients lost approximately 2x as much weight using the OPTIFAST® program

Mean change in total fat mass (kg)

OPTIFAST® program patients achieved greatest reductions in total fat mass

Mean change in waist circumference (cm)

Patients experienced greater reductions in waist circumference using the OPTIFAST® program

Sucess Stories

Everyday, OPTIFAST® is helping people like you discover that the benefits of a healthy lifestyle go far beyond weight loss. Find out what real patients have to say about their OPTIFAST® experience.

Kristin’s starting weight was 240 lbs. and her current weight is 175 lbs.* —a 65...

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Weight Loss: 65 lbs*

Kristin

Obese his whole adult life, Eugene tried everything under the sun and was never ...

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Weight Loss: 194 lbs*

Eugene

Those hiking trails that scared her a year ago now make her smile as she keeps u...

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Weight Loss: 63 lbs*

Cindy

To my great surprise, when race day came, I found myself ready to go. While it w...

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Weight Loss: 59 lbs*

Emily

VIEW ALL STORIES

OPTIFAST® studies have shown an average weight loss of approximately 30 lbs. at 26 weeks, 25 lbs. at 1 year, 19 lbs. after 2 years, and 15 lbs. after 3 years from starting the program.1,2